TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development

TGF-ß Regulates Enamel Mineralization and Maturation through KLK4 Expression

Transforming growth factor-ß (TGF-ß) signaling plays an important role in regulating crucial biological processes such as cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling. Many of these processes are also an integral part of amelogenesis. In order to delineate a precise role of TGF-ß signaling during amelogenesis, we developed a transgenic mouse line that harb...

P-183: TGF-? Level and Insulin Resistance during Normal Pregnancy

Pin1 Promotes TGF-ß-induced Migration and Invasion

*Center for Advanced Biotechnology and Medicine, Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Cancer Institute of New Jersey, Piscataway, NJ 08854 Division of Molecular Genomics and Medicine, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan, R. O. C. M...

TGF-β1 regulates TGF-β1 and FGF-2 mRNA expression during fibroblast wound healing

Aims: To evaluate the expression of transforming growth factor β1 (TGF-β1) and fibroblast growth factor 2 (FGF-2) mRNA in stromal cells in response to injury in the presence of either TGF-β1 or FGF-2. It has been shown previously that heparan sulfate proteoglycans and FGF-2 are present transiently during wound repair in vivo and that an increase in TGF-β1 mRNA is detected rapidly after injury. ...

Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-β

BACKGROUND Lung fibrosis is characterized by tissue remodeling resulting from an imbalance between synthesis and degradation of extracellular organic matrices. To examine whether cathepsin(s) (Cat) are important in the development of pulmonary fibrosis, we assessed the expression of four Cat known for their collagenolytic activity in a model of silica-induced lung fibrosis. METHODS Different ...